Friday, June 25, 2021
Home News Reports Understanding Cytokine Storm: What it is and how it may be responsible for Covid-19...

Understanding Cytokine Storm: What it is and how it may be responsible for Covid-19 related deaths

The phenomenon where the body releases too many Cytokine is known as a cytokine storm, it can trigger a severe inflammatory reaction which can be fatal

The second wave of the Covid-19 pandemic is much stronger compared to the first wave. India has been reporting the highest number of cases and causalities since April. Covid-19, unfortunately, harms the immunity of those who get infected, putting them at serious risk of getting other diseases that are comparatively rare in general. For example, the cases of black fungus or Mucormycosis are being reported in patients who have recovered from the deadly disease. Another condition that Covid-19 patients are developing is Cytokine Storm.

What is Cytokine Storm?

To understand what is Cytokine storm, first, it is essential to understand what Cytokine are. These are small glycoproteins that are produced by various types of cells in our bodies. When they are released, they promote a wide array of functions, including regulating immune and inflammatory responses. But, if the body releases far too much Cytokine, it can trigger a severe inflammatory reaction which can be fatal. The phenomenon where the body releases too many Cytokine is known as a cytokine storm.

Cytokine Storm can make immune system patient’s biggest enemy

A study done by Benedette Cuffari, M.Sc., claimed that Cytokine storm appears to play a direct role in determining the severity of SARS-CoV-2. She said, “One of the most notable clinical conditions that are associated with cytokine storms includes acute respiratory distress syndrome (ARDS), which has accounted for a significant number of deaths from SARS-CoV-2,” in her study.

Experts believe that if the Covid-19 patient gets severe Cytokine Storm and fails to get treatment in time, it can result in death. The deaths of Covid-19 patients due to multiple organ failure are believed to be caused by Cytokine Storm. Though the Cytokine are part of the Human immune response and help protect the body from various types of infection and diseases, in some Covid-19 patients, they are believed to begin to grow uncontrollably and attack the cells themselves, severely affecting the patient’s body. According to the experts, Covid-19 has the potential to make the patient’s own immune system his biggest enemy.

Cytokine storm may lead to multiple organ failure

According to a study done by Shintaro Hojyo et al., The cytokine storm in fatal COVID-19 is represented by several pathological features such as ARDS, coagulation, and multiorgan dysfunctions. Cytokine Storm can damage the lungs due to which oxygen does not reach every part of the body. It can swell up the arteries of the heart, increasing the risk of a heart attack. Also, there are chances of thrombosis or blood clotting, which can lead to sudden death. Experts believe that Cytokine Storm is more likely to happen in the second week after getting infected. Thus, the patient needs to be more cautious, and constant monitoring of the condition is necessary.

The oxygen levels fall dramatically during this Cytokine storm making it essential to shift the patient to ICU. Experts say that as Covid-19 is a comparatively new disease and a lot is still unknown about the infection, a comprehensive study is needed on the effects of Cytokine storm on the human body is necessary.

What happens in Cytokine Storm, and how is it treated?

In the case of Cytokine Storm, the body creates a substance known as Interleukin-6 (IL-6), which causes inflammation. The doctors prescribe anti-inflammatory drugs to control the effect and save the organs from any possible damage. In severe cases, the doctors may prescribe potent steroids as IL-6 blockers, but they must be taken only under the supervision of a specialist.

Counter studies questioning the role of Cytokine Storm in Covid-19 deaths

Several experts do not believe that Cytokine Storm is behind the increase in the number of deaths in Covid-19 cases. A study published in September 2020 by Matthijs Kox et al. stated that there was no direct link between Covid-19 and Cytokine Storm, as suggested.

Dr. Philip Mudd, MD, Ph.D., assistant professor of emergency medicine at Barnes-Jewish Hospital, said, “We found that cytokine storm does happen, but it’s relatively rare, even in the COVID-19 patients that go on to have respiratory failure and require a ventilator”. He added that the doctors started giving anti-inflammatory drugs without much evidence to the patients which might not help them in getting better.

According to the paper, when the researchers compared the levels of inflammatory Cytokine in Covid-19 patients with the group of patients suffering from other diseases, they did not find any evidence that suggests it was present in the Covid-19 patients. When they compared the Cytokine levels in severe Covid-19 patients who needed machine support, they did not found evidence of Cytokine Storm comparable to septic shock, which is the most common reason for Cytokine Storm.

Dr. Randy Cron, a professor of paediatrics and medicine at the University of Alabama at Birmingham, said that it is true that Covid-19 patients suffer from a higher level of Cytokine Storm, but they are not identical to the reactions caused by other disorders.

  Support Us  

Whether NDTV or 'The Wire', they never have to worry about funds. In name of saving democracy, they get money from various sources. We need your support to fight them. Please contribute whatever you can afford

OpIndia Staff
Staff reporter at OpIndia

Related Articles

Trending now

‘My statements calling out the high-handedness of Twitter have clearly ruffled its feathers’: Union IT Minister Ravi Shankar Prasad

The Union Minister of Information Technology took to Indian app Koo to share that his Twitter account had been blocked for about an hour by the global tech giant.

The spike that never came: How media made unfounded claims of 2020 festive season sparking a renewed Covid-19 surge

Media published a host of articles predicting that the festive season in 2020 would spark a COVID-19 surge. But it never happened.

The Oxygen Audit Interim Report that AAP claims does not exist was sent to Delhi govt official on 4th June: Details

Delhi govt Principal Secretary (Home) is member of oxygen audit committee, and AIIMS director had sent the interim report to him on June 4

Twitter locks Ravi Shankar Prasad’s account amidst tussle with Indian Govt, IT Minister accuses platform of violating more laws: Details

Union Minister Ravi Shankar Prasad posted a tweet saying something highly peculiar happened to his Twitter account.

Arvind Kejriwal govt tries to cover tracks, says Oxygen Audit Interim Report does not exist: Here is how they are lying blatantly

An affidavit submitted in Supreme Court shows that a copy of the interim report of Delhi's oxygen audit was sent to Delhi govt

“I went with Mantosh Saini on my will, no one pressurised me”, Fazilat Khatoon clears the air about the Madhubani ‘kidnapping’ case

Fazilat Khatoon said her parents had asked her to elope with Mantosh Saini as he is from wealthy family, and charges of kidnapping are wrong

Recently Popular

Despite all the ‘Virat Hindu’ noises Subramanian Swamy has been making, here is why I can’t trust him

Subramanian Swamy, who has been masquerading as a 'Virat Hindu', left several political dead bodies in his path while reaching the top

‘Is your father a mali or chowkidar? I will cancel your license, H*r*m*zade’: Maneka Gandhi threatens vets in viral audios

The Indian Veterinary Association in a letter have condemned the unruly behavior and unparliamentary language used by Maneka Gandhi against animal doctors.

Karnataka: Muslim family kills their own daughter and her Hindu lover in front of the boy’s mother

The 19-year-old Basavaraj Madivalapaa Badiger, an autorickshaw driver at Saladahalli village, and his 18-year-old lover Davalbi Bandagisab Tambad, a resident of the neighbouring Khanapur, were allegedly murdered by the father and other family members of the girl.

Subramanian Swamy gets desperate as rumours of cabinet reshuffle gain ground: Hubris and delusions

With rumours gaining ground that there might be a cabinet shuffle on the cards, Subramanian Swamy has now started hankering

Video of a person making anti-India comments circulated on social media falsely claiming that it is the founder of Himalaya Drug Company

Muhammad Manal, the founder of HImalaya Drug Company died in 1986, and the person in the viral video is one Naqi Ahmed Nadwi
- Advertisement -


Connect with us